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Library Toggle menubar The Jackson Laboratory Home Toggle submenu for: Therapeutic Area Autoimmune/Inflammation Essentials Immunology Immuno-oncology/Oncology Infectious Disease Metabolic Neurobiology Rare Disease Toggle submenu for: Resource Type Blog Case Studies Clinical Education Online Courses eBooks Fact Sheets Guides Livestream Videos JAX Tech Talks On-Demand Videos Online MiniCourses Portfolios White Papers Open search box Search sitewidebox Recent Searches Share this Hub Share this Hub Share on facebook Share on twitter Share on linkedin Share on email The Jackson Laboratory Learn. Engage. Connect. Latest Content Welcome to our Hub! We hope you find something interesting to read, watch and share. 22:59 23 days ago How-to Guide for Selecting Xenografts & Mouse Models for Preclinical Cancer Research If you’re gearing up to evaluate your drug candidates in clinically translatable, in vivo models, this webinar is for you. Watch Video 11:26 about 1 month ago JAX Humanized Mice PubCast: Mast cells & Anti-PD-1 Therapy (Apr. 3, 2024) Join us as we discuss a collaborative effort between academia and a biopharmaceutical company, which utilized humanized mice to explore the role of mast cells in the melanoma tumor microenvironment. Watch Video about 1 month ago Poster: Translational Humanized Models for Immunotherapy Drug Development | Immuno 2024 Read Flipbook Loading, please wait Error - something went wrong! Don’t miss new content. Subscribe to our monthly newsletter, JAX Pulse! Email Submit Close form to hide form fields Thank you! 11:33 2 months ago JAX Humanized Mice PubCast: HIV-1 in Humanized Mice (Mar. 14, 2024) In this PubCast, we discuss a study from Yale University that employed humanized PBMC-NSG mice to model HIV and test the efficacy of two novel long-acting antiretroviral delivery systems. Resource Watch Video 25:15 2 months ago What Do Experimental Mice Really Cost? In this presentation, we share a data-supported framework designed to trim costs, save time, and reduce the number of animals used for colony maintenance and cohort production. Watch Video 2 months ago Humanized NSG Mouse Models CD34 and PBMC humanized NSG mice are powerful preclinical models for studying the actions of immuno-modulators, either alone or in combination with other treatments. Read Flipbook 2 months ago Cancer immunotherapy: getting a little help from ourselves We review strategies and mouse models used to develop highly promising therapeutic treatments using the body’s own immune system in the fight against cancer. Learn More 3 months ago Intersectional Genetics: Cre-lox with a twist Limitations to scientific progress often arise not from a lack of curiosity or imagination, but rather from the tools and technologies available. While some research questions can be sufficiently... Learn More 40:17 3 months ago Comparing Immune-Humanized Mouse Platforms for Preclinical Applications February 20, 2024 - During this presentation, we compare strategies for immune humanization of NSG variants to support translatable preclinical immunology and oncology research. Watch Video 43:15 3 months ago Using Cre-lox Technology in Mouse Modeling In this webinar, we discuss cre-lox technology, a widely used and sophisticated tool to create general knockouts, conditional knockouts, and reporter strains. Watch Video 3 months ago 7 tips for developing evidence-based online education for clinicians We recently published a paper in Journal of Genetic Counseling outlining our successful team-based approach to developing education for cardiology clinicians. Our collaboration with clinical and... Learn More 46:08 4 months ago Designing Reproducible Preclinical Research Studies During this seminar, we discuss unique experimental design considerations for mouse-based research. Watch Video 4 months ago Tips to Design Successful Immuno-Oncology Efficacy Studies to Push Drug Discovery Further If you have ever screened a compound library and successfully killed tumor cells in a dish, you might be surprised to find that many of those compounds may have little or no effect when those... Learn More 4 months ago Top Tips on Selecting the Best” Immunodeficient Mouse Model for Your Research Immunodeficient mice are invaluable tools for immunology, infectious disease, oncology, hematopoietic, and regenerative medicine studies. They can serve as hosts for engraftment of mouse tumor... Learn More 41:36 4 months ago Comparing Immunodeficient Models for Cancer, Immunity, and Transplant Research January 16, 2024 - In this webinar, we discuss the most widely used immunodeficient mouse models and essential considerations for selecting the most appropriate model. Watch Video 4 months ago On the cusp? I started covering the field of human genomics in depth around 2008. It was a time when whole genome sequencing (WGS) still cost millions of dollars per genome, and genome editing methods were so... Learn More 5 months ago Aged C57BL/6J Mice for Research Studies Read Flipbook 15:42 5 months ago JAX Tech Talk Episode 69: Let’s Talk Model Acquisition and Genetic Integrity (Dec. 12, 2023) In this episode, we discuss the common discrepancies we encounter when strains are imported into The Jackson Laboratory’s repository and how JAX ensures our strains meet our high standards. Watch Video 46:35 5 months ago The Consequences of Sex Bias in Preclinical Research Omitting sex as a biological variable has several consequences. Watch this webinar to learn the scientific impact sex bias has on your research. Watch Video 42:54 5 months ago Rapid In Vivo Evaluation of Immuno-Modulatory Therapies Using Hu-PBMC NSG™ Mice Learn about Hu-PBMC NSG models that can be used to test the efficacy of human T cell immunomodulatory therapeutics for graft-versus-host disease (GvHD), autoimmune disorders, and cancer. Watch Video Loading More... © The...